You did not respond to the answer, so we cannot see what answer you were given.
Consider this,
Sometimes Toad will become disconnected due to timeout, inactivity. When you try to run a script in this state, sometimes it will hang. When you receive the notice to reconnect, sometimes it will recover sometimes it will not.
But as the answer stated please provide more information, messages notifications......
Lately, I make sure I am still connected, before running any query, especially a large one. menu, session, reconnect.